Project list research area D: Nutrition, metabolism and health

D1- Cell

List of ongoing PhD projects (as of 15 June 2010).
In order to contact the respective PhD students (or supervisors) you are referred to the website of the university/institute where the research is done (see participating groups).

PhD student M.E. Adriaens (Michiel), BiGCaT Bioinformatics, MUMC+
Project titleGenome wide analysis of ChIP and MeDIP microarray data.
Supervisors Dr. C.T.A. Evelo, BiGCaT Bioinformatics, MUMC+
 
PhD student M.T.J. van Ampting (Marleen), NIZO food research
Project titleNutrients and gut infection.
Supervisors Prof. R.J. Brummer, Internal Medicine, MUMC+
Dr. I.M.J. Bovee-Oudenhoven, NIZO food research
Dr. R. van der Meer, Human Nutrition, WU
 
PhD student J. van Berkel (Joep), Health Risk Analysis and Toxicology, MUMC+
Project titleAnalysis of exhaled air as indicator for in vivo chronic oxidative stress in COPD patients.
Supervisors Prof. F.J. van Schooten, GRAT, MUMC+
Prof. E.F.M. Wouters, Respiratory Medicine, MUMC+
Dr. J. Dallinga, GRAT, MUMC+
Dr. R.W.L. Godschalk, GRAT, MUMC+
 
PhD student V. Bieghs (Veerle), Genetics and Cell Biology, MUMC+
Project titleKupffer cells in the driver's seat of non-alcoholic steatohepatitis.
Supervisors Prof. M.H. Hofker, Pathology & Laboratory Medicine, UMCG, RuG
Dr. R. Shiri-Sverdlov, Genetics and Cell Biology, MUMC+
 
PhD student L. Bilet (Lena), Human Biology, MUMC+
Project titleMitochondrial lipotoxicity and diabetes: human studies.
Supervisors Dr. P. Schrauwen, Human Biology, MUMC+
Dr. M.K.C. Hesselink, Movement Sciences, MUMC+
 
PhD student B. van den Bogert (Tom), Microbiology, WU
Project titlePopulation dynamics of human small intestinal microbiota.
Supervisors Prof. M. Kleerebezem, NIZO food research
Dr. E.G. Zoetendal, Microbiology, WU
Dr. G.W. Welling, Medical Microbiology, UMCG, RuG
 
PhD student D. Booi (Darren), Surgery, MUMC+
Project titleArginine and IR-injury with a free flap model (free-TRAM-flap)
Supervisors Prof. R.R.W.J. van der Hulst, Plastic, Reconstructive and Hand Surgery, MUMC+
Dr. N.E.P. Deutz, Surgery, MUMC+
 
PhD student M. Bosma (Madeleen), Human Biology, MUMC+
Project titleMuscular lipid droplet dynamics: the role of novel lipid-coating proteins in lipid droplet formation and hydrolysis.
Supervisors Dr. P. Schrauwen, Human Biology, MUMC+
Dr. M.K.C. Hesselink, Movement Sciences, MUMC+
Dr. S. Kersten, Human Nutrition, WU
 
PhD student C.E. Bragt (Marjolijn), Human Biology, MUMC+
Project titleThe role of peroxisome proliferator-activated receptors α and γ in the metabolic syndrome.
Supervisors Prof. R.P. Mensink, Human Biology, MUMC+
 
PhD student B.W.J. van Bree (Bianca), Human Biology, MUMC+
Project titleMitochondrial lipotoxicity and type 2 diabetes mellitus: animal studies.
Supervisors Dr. P. Schrauwen, Human Biology, MUMC+
 
PhD student B.C.T. van Bussel (Bas), Internal Medicine, MUMC+
Project titleDiet and and early changes in endothelial function.
Supervisors Prof. C.D.A. Stehouwer, Internal Medicine, MUMC+
Dr. C.G. Schalkwijk, Internal Medicine, MUMC+
Dr. R.M.A. Henry, Internal Medicine, MUMC+
 
PhD student R.H.E. Cloots (Roy), Anatomy & Embryology, MUMC+
Project titleArginase: Effector or bystander molecule in asthma?
Supervisors Prof. W.H. Lamers, Anatomy & Embryology, MUMC+
Dr. E.S. Köhler, Anatomy & Embryology, MUMC+
 
PhD student T.C. Comhair (Tine), Anatomy & Embryology, MUMC+
Project titleMetabolic and signaling pathways in steatosis and steatohepatitis
Supervisors Prof. W.H. Lamers, Anatomy & Embryology, MUMC+
Prof. C.H.C. Dejong, Surgery, MUMC+
Dr. E.S. Köhler, Anatomy & Embryology, MUMC+
 
PhD student J.C.M. Coolen (Erik), Epidemiology, MUMC+
Project titleOral administration of ATP.
Supervisors Prof. P.A. van den Brandt, Epidemiology, MUMC+
Prof. A. Bast, Pharmacology and Toxicology, MUMC+
Prof. M.A. Cohen Stuart, PCC, WU
Dr. P.C. Dagnelie, Epidemiology, MUMC+
 
PhD student S. El-Aidy (Sahar), Microbiology, WU
Project titleMicrobial modulation of intestinal epithelial integrity.
Supervisors Prof. M. Kleerebezem, NIZO food research
Dr. E.G. Zoetendal, Microbiology, WU
 
PhD student E. Elamin (Elhaseen), Internal Medicine, MUMC+
Project titleClinical studies of the effects of nutrition on epithelial permeability of the human intestine.
Supervisors Prof. A.M. Masclee, Internal Medicine, MUMC+
Dr. D.M.A.E. Jonkers, Internal Medicine, MUMC+
Dr. F.J. Troost, Internal Medicine, MUMC+
 
PhD student D. Esser (Diederik), Human Nutrition, WU
Project titleDiet and early changes in endothelial function.
Supervisors Prof. M. Müller, Human Nutrition, WU
Dr. L.A. Afman, Human Nutrition, WU
 
PhD student S. Gaj (Stan), Human Biology, MUMC+
Project titleEffects of short-term dietary intervention on molecular signatures in man.
Supervisors Prof. R.P. Mensink, Human Biology, MUMC+
Dr. C.T.A. Evelo, BiGCaT Bioinformatics, MUMC+
 
PhD student A.G. Georgiadi (Anastasia), Human Nutrition, WU
Project titleThe role of PPARalpha in regulation of gene expression in heart.
Supervisors Prof. M. Müller, Human Nutrition, WU
Dr. S. Kersten, Human Nutrition, WU
 
PhD student J. Grootjans (Joep), Surgery, MUMC+
Project titleHuman intestinal ischemia-reperfusion.
Supervisors Prof. W.A. Buurman, Surgery, MUMC+
Prof. C.H.C. Dejong, Surgery, MUMC+
 
PhD student J.J. de Haan (Jacco Juri), Surgery, MUMC+
Project titleLipid rich nutrition as cure for intestinal inflammation.
Supervisors Prof. W.A. Buurman, Surgery, MUMC+
Prof. J.W.M. Greve, Surgery, Atrium MC
 
PhD student D. Haenen (Daniëlle), Human Nutrition, WU
Project titleFermentation in the gut prolongs satiety.
Supervisors Prof. M. Müller, Human Nutrition, WU
Prof. B. Kemp, Adaptation Physiology, WU
Dr. G.J.E.J. Hooiveld, Human Nutrition, WU
 
PhD student A.M.J. van Hees (Anneke), Human Biology, MUMC+
Project titleLIPGENE: Interaction of nutrients and genotype in the metabolic syndrome.
Supervisors Prof. W.H.M. Saris, Human Biology, MUMC+
Prof. E.E. Blaak, Human Biology, MUMC+
 
PhD student M.G.W. van den Heuvel (Marieke), Surgery, MUMC+
Project titleThe DIEP-flap as a model for ischemia-reperfusion.
Supervisors
 
PhD student C. Hodin (Caroline), Surgery, MUMC+
Project titleLeaky gut, intestinal ischemia.
Supervisors Prof. W.A. Buurman, Surgery, MUMC+
Prof. E. Heineman, Surgery, UMCG, RuG
Dr. K. Lenaerts, Surgery, MUMC+
 
PhD student M. van Iersel (Martijn), BiGCaT Bioinformatics, MUMC+
Project titleAn integrated bioinformatics approach for the functional analysis of transcriptomic and proteomic expression data in nutritional studies
Supervisors Prof. E.C.M. Mariman, Human Biology, MUMC+
Prof. T. Burzykowski, CENSTAT Universiteit Hasselt, Belgium
Dr. C.T.A. Evelo, BiGCaT Bioinformatics, MUMC+
 
PhD student N. IJssennagger (Noortje), Human Nutrition, WU
Project titleNutritional and microbial modulation of intestinal epithelial integrity.
Supervisors Prof. M. Müller, Human Nutrition, WU
Dr. R. van der Meer, Human Nutrition, WU
Dr. A. Rijnierse, Human Nutrition, WU
 
PhD student A. Jans (Anneke), Human Biology, MUMC+
Project titleSkeletal muscle lipid metabolism and insulin sensitivity: Can dietary fatty acid composition modulate muscle lipid storage?
Supervisors Prof. E.E. Blaak, Human Biology, MUMC+
 
PhD student H.J.I. de Jong (Hilda), Health Risk Analysis and Toxicology, MUMC+
Project titleChronic drug use and autoimmunity.
Supervisors Prof. H. van Loveren, GRAT, MUMC+
Prof. J.W. Cohen Tervaert, Internal Medicine, MUMC+
Dr. R.J. Vandebriel, RIVM
Dr. O.H. Klungel, Pharmaceutical Science, UU
 
PhD student P. Karimi Elizee (Pegah), Internal Medicine, MUMC+
Project titleThe role of innate defense, microbiota and pouch function in the development of pouchitis after ileoanal pouch reconstruction.
Supervisors Prof. A.M. Masclee, Internal Medicine, MUMC+
Dr. D.M.A.E. Jonkers, Internal Medicine, MUMC+
Dr. M.J. Pierik, Internal Medicine, MUMC+
 
PhD student T. Kelder (Thomas), BiGCaT Bioinformatics, MUMC+
Project titleOnline applications for scientific collaboration directed towards functional analysis of genomics results in the context of biological pathways.
Supervisors Dr. C.T.A. Evelo, BiGCaT Bioinformatics, MUMC+
 
PhD student M.Y. Kessels (Maurijn), Biochemistry, WU
Project titleBiomineral formation in zebrafish
Supervisors Prof. S.C. de Vries, Biochemistry, WU
Prof. S. Schulte-Merker
Dr. S. Kranenbarg
 
PhD student D. Keszthelyi (Daniel), Internal Medicine, MUMC+
Project titleNutritional modulation of intestinal permeability.
Supervisors Prof. A.M. Masclee, Internal Medicine, MUMC+
Dr. F.J. Troost, Internal Medicine, MUMC+
 
PhD student B. de Koning (Bart), Microbiology, WU
Project titleUnravelling eukaryal-like control networks in archaea.
Supervisors Prof. J. van der Oost, Microbiology, WU
Dr. S.J.J. Brouns, Microbiology, WU
 
PhD student P.P. Kovatcheva-Datchary (Petia), Microbiology, WU
Project titleMicrobe-mediated gut metabolism.
Supervisors Prof. W.M. de Vos, Microbiology, WU
Dr. H. Smidt, Microbiology, WU
Dr. K. Venema, TNO Quality of Life
 
PhD student I. Kuipers (Ine), Respiratory Medicine, MUMC+
Project titleRole of glutaredoxins in COPD.
Supervisors Prof. E.F.M. Wouters, Respiratory Medicine, MUMC+
Dr. N.L. Reynaert, Respiratory Medicine, MUMC+
Prof. Y. Janssen-Heininger, Pathology, University of Vermont
 
PhD student M.M. Leimena (Milkha), Microbiology, WU
Project titleMetagenomics of the small intestinal microbiota.
Supervisors Prof. M. Kleerebezem, NIZO food research
Dr. E.G. Zoetendal, Microbiology, WU
 
PhD student E. Lenaers (Ellen), Movement Sciences, MUMC+
Project titleMuscle mitochondrial funtion during the development of diabetes in ZDF rats.
Supervisors Prof. W.H.M. Saris, Human Biology, MUMC+
Dr. M.K.C. Hesselink, Movement Sciences, MUMC+
Dr. P. Schrauwen, Human Biology, MUMC+
 
PhD student L.M.P. Loonen (Linda), Host-Microbe Interactomics, WU
Project titleMicrobial and nutritional modulation of defensive (glyco)proteins and peptides from Paneth cells and goblet cells: their use as biomarkers of epithelial integrity.
Supervisors Prof. J.M. Wells, Host-Microbe Interactomics, WU
Dr. J.M. Karczewski, Host-Microbe Interactomics, WU
 
PhD student T. Lubbers (Tim), Surgery, MUMC+
Project titleThe anti-inflammatory mechanism of lipid-rich enteral nutrition.
Supervisors Prof. W.A. Buurman, Surgery, MUMC+
Prof. J.W.M. Greve, Surgery, Atrium MC
 
PhD student R.A. Matthijsen (Robert), Surgery, MUMC+
Project titleMechanisms underlying propagation of apoptosis in the heart following ischemia and reperfusion.
Supervisors Prof. W.A. Buurman, Surgery, MUMC+
 
PhD student F.B.J. Mattijssen (Frits), Human Nutrition, WU
Project titleProbing the role and regulation of plasma ANGPTL4 in mouse and human: a potential biomarker for metabolic syndrome.
Supervisors Prof. M. Müller, Human Nutrition, WU
Dr. S. Kersten, Human Nutrition, WU
 
PhD student R. Meex (Ruth), Movement Sciences, MUMC+
Project titleSetting fat on fire.
Supervisors Dr. M.K.C. Hesselink, Movement Sciences, MUMC+
Dr. P. Schrauwen, Human Biology, MUMC+
 
PhD student M. Meijerink (Marjolein), Host-Microbe Interactomics, WU
Project titleMolecular mechanism of host responses to probiotics.
Supervisors Prof. J.M. Wells, Host-Microbe Interactomics, WU
Prof. H.F.J. Savelkoul, Cell Biology and Immunology, WU
Dr. J. van Bilsen, TNO Quality of Life
 
PhD student L.E.C. van Meijl (Leonie), Human Biology, MUMC+
Project titleThe effects of low-fat dairy on metabolic risk parameters in subjects with the metabolic syndrome.
Supervisors Prof. R.P. Mensink, Human Biology, MUMC+
 
PhD student C.C.M. Moors (Chantalle), Human Biology, MUMC+
Project titleReversing ectopic fat acculation: a pharmacological approach to identify underlying mechanisms.
Supervisors Prof. E.E. Blaak, Human Biology, MUMC+
Dr. G.H. Goossens, Human Biology, MUMC+
Prof. M. Diamant, Endocrinology, VUmc
 
PhD student L. Mpabanzi (Liliane), Surgery, MUMC+
Project titleModulation of ammoniagenesis in patients with hepatic encephalopathy.
Supervisors Prof. C.H.C. Dejong, Surgery, MUMC+
Dr. S.W.M. Olde Damink, Surgery, MUMC+
 
PhD student M. Ohid Ullah (Mohammad), Human Nutrition, WU
Project titleSystems biology of fatty acid sensing.
Supervisors Prof. M. Müller, Human Nutrition, WU
Dr. G.J.E.J. Hooiveld, Human Nutrition, WU
 
PhD student N.A.M. Pansters (Nicky), Respiratory Medicine, MUMC+
Project title'Make or break' skeletal muscle: regulation of muscle plastricity by GSK-3b.
Supervisors Prof. A.M.W.J. Schols, Respiratory Medicine, MUMC+
Dr. R.C.J. Langen, Respiratory Medicine, MUMC+
 
PhD student P.M.P. Peeters (Paul), Respiratory Medicine, MUMC+
Project titleGene profiling of LPS- and benzoapyrene-coated crystalline silica in lung epithelial cells and fibroblasts.
Supervisors Prof. E.F.M. Wouters, Respiratory Medicine, MUMC+
Prof. B.T. Mossman, Pathology, University of Vermont
Dr. N.L. Reynaert, Respiratory Medicine, MUMC+
 
PhD student B.P.A. Pennings (Bart), Movement Sciences, MUMC+
Project titleMuscle protein synthetic response to food intake with ageing.
Supervisors Prof. H. Kuipers, Movement Sciences, MUMC+
Dr. L.J.C. van Loon, Movement Sciences, MUMC+
 
PhD student M. Rakhshandehroo (Maryam), Human Nutrition, WU
Project titleThe role of PPARs in human liver.
Supervisors Prof. M. Müller, Human Nutrition, WU
Dr. S. Kersten, Human Nutrition, WU
 
PhD student A. Rosenow (Anja), Human Biology, MUMC+
Project titleIdentification and validation of novel human adipokines.
Supervisors Prof. E.C.M. Mariman, Human Biology, MUMC+
Dr. J.W. Renes, Human Biology, MUMC+
 
PhD student O.R. Rossi (Oriana), Host-Microbe Interactomics, WU
Project titleInteractions of probiotics and commensal bacteria with the gut mucosa and in vivo trafficking.
Supervisors Prof. J.M. Wells, Host-Microbe Interactomics, WU
Dr. M. Rescigno, Instituto Europeo di Oncologia, Italy
 
PhD student J. Saito (Jahn-Takeshi), BiGCaT Bioinformatics, MUMC+
Project title
Supervisors
 
PhD student S. Sankaranarayanan (Selvakumari), Anatomy & Embryology, MUMC+
Project titleRole of arginine in B-cell development.
Supervisors Prof. W.H. Lamers, Anatomy & Embryology, MUMC+
Dr. E.S. Köhler, Anatomy & Embryology, MUMC+
 
PhD student M.A.A. Schepens (Marloes), NIZO food research
Project titleDietary modulation of resistance to gut infection and associated mucosal inflammation.
Supervisors Prof. R.J. Brummer, Internal Medicine, MUMC+
Dr. I.M.J. Bovee-Oudenhoven, NIZO food research
Dr. R. van der Meer, Human Nutrition, WU
 
PhD student M. Stolaki (Maria), Microbiology, WU
Project titleDevelopment of a human dynamic in vitro system for the human ileum.
Supervisors Prof. M. Kleerebezem, NIZO food research
Dr. K. Venema, TNO Quality of Life
Dr. E.G. Zoetendal, Microbiology, WU
 
PhD student A. Van Summeren (Anke), Human Biology, MUMC+
Project titleProteomics investigation towards mechanisms and biomarkers for hepatotoxicity.
Supervisors Prof. E.C.M. Mariman, Human Biology, MUMC+
Prof. J.C.S. Kleinjans, GRAT, MUMC+
Dr. J.W. Renes, Human Biology, MUMC+
Dr. J.H.M. van Delft, GRAT, MUMC+
 
PhD student F. van Tienen (Florence), Genetics and Cell Biology, MUMC+
Project titleElucidation of predictive, pathological changes in OXPHOS genes, gene expression and activity in type 2 diabetes.
Supervisors Prof. J.P.M. Geraedts, Genetics and Cell Biology, MUMC+
Dr. H.J.M. Smeets, Genetics and Cell Biology, MUMC+
 
PhD student S. Tims (Sebastian), Microbiology, WU
Project titleMetagenomics of the human intestinal tract.
Supervisors Prof. M. Kleerebezem, NIZO food research
Dr. E.G. Zoetendal, Microbiology, WU
 
PhD student S.A.L.W. Vanhoutvin (Steven), Internal Medicine, MUMC+
Project titleNew techniques related to gut health.
Supervisors Prof. R.J. Brummer, Internal Medicine, MUMC+
Dr. F.J. Troost, Internal Medicine, MUMC+
Dr. D.M.A.E. Jonkers, Internal Medicine, MUMC+
 
PhD student F.J. Verdam (Froukje), Surgery, MUMC+
Project titleThe role of intestinal integrity in the development of insulin resistance and non-alcoholic steatohepatitis in the obese population.
Supervisors Prof. J.W.M. Greve, Surgery, Atrium MC
Prof. W.A. Buurman, Surgery, MUMC+
Dr. S.S. Rensen, Surgery, MUMC+
 
PhD student K.J.P. Verhees (Koen), Respiratory Medicine, MUMC+
Project title'Make or break' skeletal muscle: regulation of muscle plasticity by GSK-3beta.
Supervisors Prof. A.M.W.J. Schols, Respiratory Medicine, MUMC+
Dr. R.C.J. Langen, Respiratory Medicine, MUMC+
 
PhD student I.C. Vermeulen Windsant (Iris), Surgery, MUMC+
Project titleStudy on the changes in arginine/NO metabolism and inflammation around TAAA repair as a possible cause of post-operative complications
Supervisors Prof. M.J.H.M. Jacobs, Surgery, MUMC+
Prof. W.A. Buurman, Surgery, MUMC+
 
PhD student G.H.E.J. Vijgen (Guy), Surgery, MUMC+
Project titleBrown adipose tissue in morbid obesity.
Supervisors Dr. W.D. van Marken Lichtenbelt, Human Biology, MUMC+
Dr. N.D. Bouvy, Surgery, MUMC+
 
PhD student R.G.J. Visschers (Ruben), Surgery, MUMC+
Project titleOptimisation of the treatment of patients with an enterocutaneous fistula.
Supervisors Prof. P.B. Soeters, Surgery, MUMC+
Dr. W.G. van Gemert, Surgery, Atrium MC
Dr. S.W.M. Olde Damink, Surgery, MUMC+
 
PhD student K.M.E. Wehrens (Kim), Surgery, MUMC+
Project titlePreventing progression of burn depth (and enhancing wound healing) by supplementation of pharmaco-nutrients in a mice cutaneous burn wound model.
Supervisors Prof. R.R.W.J. van der Hulst, Plastic, Reconstructive and Hand Surgery, MUMC+
 
PhD student C.H. van de Weijer (Tineke), Human Biology, MUMC+
Project titleMitochondrial function in diabetic dilated cardiomyopathy.
Supervisors Dr. P. Schrauwen, Human Biology, MUMC+
Dr. V.B. Schrauwen-Hinderling, Radiology, AzM
Dr. M.K.C. Hesselink, Movement Sciences, MUMC+
 
PhD student K. van Wijck (Kim), Surgery, MUMC+
Project titleExercise as a gastrointestinal stress model: a human study.
Supervisors Prof. W.A. Buurman, Surgery, MUMC+
Dr. C.H.C. Dejong, Surgery, MUMC+
 
PhD student J. de Wilde (Janneke), Human Biology, MUMC+
Project titleMolecular regulation of skeletal muscle function by dietary factors.
Supervisors Prof. E.C.M. Mariman, Human Biology, MUMC+
 
PhD student J. Zhang (Jing), Microbiology, WU
Project titleEffect of host genotype on porcine gastrointestinal microbiota structure and function.
Supervisors Prof. W.M. de Vos, Microbiology, WU
Dr. H. Smidt, Microbiology, WU