Obesity represents one of the most significant health and socioeconomic burdens to modern society. Lignans are bioactive compounds in plant-based food are commonly consumed in diets worldwide and can be an important part of an effective strategy to help prevent and manage obesity. However, precise associations between the consumption of lignan foods and obesity have not been reported extensively. Therefore, this thesis aimed to look at the definition of phytoestrogens, particularly lignans, the lignan content of various foods, their absorption in the human large intestine. Further, we assessed the lignans food intake in relation to obesity indicators in a Dutch population. Collectively, the findings from indicate the potential for further exploring the lignan content in foods, and processing techniques to increase the absorption of lignans. The current research could aid in the development of low-cost and time-saving food with manifold healthy properties.