Enzymes are used in various industrial processes ranging from the ton scale conversion of starch to the gram scale synthesis of active pharmaceutical ingredients. The enzymes used in these industrial processes need to be robust, cheap and work under varying conditions. This masterclass will provide detailed information on the basic principles of enzymes, their engineering and immobilisation, and matters relevant to their industrial use. In addition, emerging fields such as use of enzymes in combination with chemical catalysts, alternative cofactors, enzyme nanoreactors and the use of enzymes in the lab on a chip will be discussed. A special session will deal with the future possibilities of CRISP-Cas technologies. Also issues relevant to industrial practice such as intellectual property will be presented.
The course is at graduate level. The course will be valuable for those who are working with enzymes in academia and industry, or are considering to do so.
The masterclass consists of a number of lectures given by experts from academia and industry and provides ample opportunity to exchange knowledge with the experts as well as the participants. Attention will be paid to:
- Basic principles of enzyms including structure, function, kinetics, stability and inhibition
- Enzyme immobilization
- Industrial production and downstream processing
- Enantioselectivity and promiscuity of enzymes
- Redox enzymes
- Enzymes in nanoreactors and the lab on a chip
- Enzyme engineering in theory and practice
- CRISPR-Cas technologies
- Dr M.C.R. Franssen; Organic Chemistry, VLAG, Wageningen University, NL
- Prof. W.J.H. van Berkel; Food Chemistry, VLAG, Wageningen University & Research, NL
- Prof. M.J.E.C. van der Maarel; Aquatic Biotechnology and Bioproduct Engineering, ENTEG, University of Groningen
- Prof. M. Fraaije; Faculty of Science and Engineering, University of Groningen, NL
- Dr D.C. Swarts, Wageningen University & Research, NL
- Prof. M.H.M. Eppink; Synthon, Wageningen University & Research, NL
- Prof. J. van der Oost, Wageningen University & Research, NL
- Prof. U. Hanefeld; Delft University of Technology, NL
- Dr S. Hartmans; DSM, Delft, NL
- Dr H.J. Wijma; University of Groningen, NL
- Prof. J.C.M. van Hest; Eindhoven University of Technology, NL
- Prof. J. Woodley; Technical University of Denmark, DK
- Dr R. de Jong, DSM, Delft, NL
- Prof. G.J. Poelarends; University of Groningen, NL
Date & duration
The course will be held from 29 April - 1 May 2019, 3 days.
The course language will be English.
The study load of this course is 0.9 ECTS credits for attending all lectures.
Location & accommodation
Lectures will be given at Wageningen University. Wageningen is located 5 kms from the train station of Ede-Wageningen. This railway station can be reached by train from the airport Schiphol in about one hour.
The organization has blocked a number of hotel rooms at Wageningen International Hotel and Congress Centre (WICC) for course participants, but only until 18 March 2019. Single room 69 euro per night, twin room, single use 74,50 euro per night including breakfast, excluding taxes. Transport to Wageningen Campus by bus (public transport) or bike (to be rent at the hotel). Participants have to book their own room. Please book your room before 17 March 2019 and mention bonus code AB19: http://www.wicc.nl/
Another option is to book a Bed & breakfast: https://classic.bedandbreakfast.nl/bed-and-breakfast/wageningen/netherlands/c2745088
Registration & course fee
To register please complete the electronic reply form
The final registration date has been extended to 9 April 2019.
Registrations will be accepted in the order in which the registration form and course fee payment are received. Applicants will be informed of acceptance of their registration by E-mail. They will receive instructions for payment, and further course details.
Course fee includes downloadable lecture notes, wi-fi internet access, coffee/tea during breaks, lunches, and one dinner, and but does not cover accommodation. The course fee depends on the participant's affiliation:
| VLAG / WUR / ENTEG PhD candidates
|| € 225
| All other PhD candidates and VLAG postdocs & staff
|| € 450
| Postdocs, and other academic staff / Non-Profit
|| € 625
| Industry / For-Profit
|| € 1200
- No charge until 9 April 2019
- 25% of the course fee paid or due till 22 April 2019
- No refund after 22 April 2019
Substitutions for participants may be made at any time until the start of the course.
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