PhD defence

Glycosylation of FIP-nha and its biological properties

PhD candidate Y (Yusi) Liu
External promotor Prof. Dr Harry J. Wichers
Co-promotor S (Shanna) Bastiaan-Net
dr. T (Tamara) Hoppenbrouwers
External copromotor Prof. Dr Fengjiao Xin
Organisation Wageningen University, Wageningen Food & Biobased Research, Wageningen Food & Biobased Research

Wed 17 April 2024 13:30 to 15:00

Venue Omnia, building number 105
Hoge Steeg 2
6708 PH Wageningen
+31 (0) 317 - 484500
Room Auditorium


The thesis studied the structure, characteristics and biofunction of FIP-nha, and how glycosylation impacts the structure and stability of FIP-nha, as well as the impact on FIP-nha’s anti-tumour activity via regulating innate immune cells (macrophages). We determined the crystal structure of rFIP-nha, and investigated the correlation linkage of structure and thermostability, and glycosylation impacts on hydrolysis resistance. Meanwhile, the immunomodulatory activity of rFIP-nha on macrophage polarization and tumour scavenging activity was investigated. In addition, the underlying mechanism was further explored, which contributes to a deeper understanding of FIP-nha’s anti-tumour activity.